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  1. Do You Have COMT Gene Mutation, COMT Symptoms & Testing

    What are COMT gene mutations? A COMT gene mutation, specifically COMT gene polymorphisms, affects the production of your COMT enzyme. The COMT enzyme activity …

  2. What Is the COMT Gene? And How Does It Affect Your Health?

    Nov 4, 2025 · Chronically stressed? Can't shake the blues? It could be your genes! In part 2 of this series, learn about how the COMT gene can affect health and well-being.

  3. The COMT Mutation: How It Impacts Stress and Strategies for …

    Between 20 and 30 percent of Caucasians with European ancestry have a COMT mutation. This mutation limits the body’s ability to break down and remove neurotransmitters (NTs) by 3-4 …

  4. How the COMT Gene Impacts Mental Health Treatment - Genomind

    Feb 23, 2023 · The relative lack of dopamine transporters in the PFC means that dopamine levels in the PFC are largely determined by activity of the COMT enzyme. If clinically indicated, …

  5. COMT Gene - COMT enzyme and its importance - MTHFR Doctors

    COMT helps the body get rid of excess Dopamine and other neurotransmitters as well as excess estrogens. A homozygous mutation of the V158M allele is associated with a 40% reduction in …

  6. Do You Have Fast or Low COMT Genes? Mental Health Symptoms …

    Aug 2, 2024 · Understanding your COMT gene type can provide valuable insights into your mental health, as it may be linked to specific symptoms and risks, such as anxiety, depression, and …

  7. Understanding COMT Mutations – a Comprehensive Guide

    Sep 28, 2023 · Like any other gene, the COMT gene is susceptible to mutations. This mutation affects the production of the COMT enzyme, thereby impacting the body’s ability to degrade …

  8. COMT gene: MedlinePlus Genetics

    Variations in the COMT gene are among many factors under study to help explain the causes of schizophrenia. A large number of genetic and lifestyle factors, most of which remain unknown, …

  9. What Is a COMT Mutation and How Does It Affect You?

    The COMT gene can have variations in its DNA sequence, common among individuals and not considered disease-causing mutations. These variations are often single nucleotide …

  10. COMT Gene Mutation and its Impact on Health

    Jan 17, 2025 · Mutations in the COMT gene can impact the efficiency of neurotransmitter breakdown, leading to various health conditions, including mental health disorders and …