JAK enzymes are part of the JAK/STAT pathway. This signaling pathway transmits chemical signals from the outside of cells, specifically lymphocytes, and into the cell nucleus.

Sep 5, 2025 · A JAK2 mutation is a change in the gene that can cause uncontrolled blood cell production. JAK2 mutations are linked to blood cancers and disorders like polycythemia vera and …

Jul 15, 2025 · Janus kinase (JAK) inhibitors are a group of medicines that help block immune system signals in the body that can lead to swelling (inflammation) and pain in conditions like rheumatoid …

4 days ago · The FDA approved 3 new drugs in the dermatology space in 2025. Zevaskyn, the first gene therapy for recessive dystrophic epidermolysis bullosa, showed significant wound healing in phase 3 …

Aug 13, 2024 · Janus kinase (JAK) inhibitors are a group of medications with many uses. Rinvoq (upadacitinib), Xeljanz (tofacitinib), and Cibinqo (abrocitinib) are options for eczema and other …

Learn how JAK inhibitors treat autoimmune conditions like rheumatoid arthritis and psoriasis. Discover their benefits, side effects, and mechanism of action.

Janus kinase or “just another kinase” (JAK) is a family of intracellular, non-receptor tyrosine kinase enzymes that convert cytokine-mediated signals via the JAK- STAT pathway into nuclear effects.

Oct 22, 2025 · The Janus kinases (JAKs) are protein tyrosine kinases (TYKs) that bind to transmembrane type 1 and type 2 cytokine receptors and mediate cellular responses to numerous …

Jul 28, 2025 · The JAK-signal transducer and activator of transcription (STAT) pathway is central to immune dysregulation in many autoimmune diseases due to its role in transducing signals from an …

Aug 8, 2024 · JAK proteins—the targets of JAK inhibitors—are like puppet masters, pulling the strings that control numerous cellular functions, including inflammation and immune cell activity.