DNA phosphorothioate modification is a distinctive epigenetic alteration in which a non‐bridging oxygen atom within the DNA sugar-phosphate backbone is replaced by ...

A UCLA-led study has provided an unprecedented look at how gene regulation evolves during human brain development, showing how the 3D structure of chromatin - DNA and proteins - plays a critical role.

Cells contain a blueprint in the form of DNA that dictates what they can make. This blueprint is converted into a message ...

A new study has created a map of DNA modification in two regions of the brain critical to learning, memory and emotional regulation. The map offers a benchmark for ensuring stem cell-based models ...

The Human Genome Project changed everything. A map of the entire human sequence of DNA was the starting point for an enormous number of discoveries, from disease genes to how humans evolved. But DNA ...

Collaborating researchers have made a breakthrough discovery regarding the intricate defense systems of bacteriophages (phages)—viruses that can specifically target harmful bacteria without harming ...

The bacteria that cause tuberculosis (TB) may have an 'on-off switch' that lets them pause and restart growth, according to a new study. The research helps explain why TB is so hard to treat with ...

LMU molecular biologist Gunnar Schotta has investigated which mechanisms prevent endogenous retroviruses from becoming overly active. Endogenous retroviruses (ERVs) have established themselves in the ...

DNA is often seen as the blueprint of life—carrying the code to govern the development and traits of an organism—but “there are things beyond the DNA sequence,” says Xiaoqi Feng, a plant geneticist at ...

Nano-tRNAseq is based on nanopore sequencing, a technology that can directly sequence individual RNA molecules by passing them through a small pore. Each of the nucleotides that compose an RNA ...

Researchers from the Perelman School of Medicine at the University of Pennsylvania have invented a new way to map specific DNA markings called 5-methylcytosine (5mC) which regulate gene expression and ...